Just 10 years ago, the Atacama Desert was almost completely unknown to the North American traveler. Accessible only to backpackers and the savviest of travelers, this unique area—which reminds me of Yellowstone, the American Southwest, and Mars all rolled into one—was a hidden gem.

Today, the gorgeous landscapes combined with the fascinating pre-Columbian indigenous cultures have turned the region into one of Chile’s top attractions alongside Patagonia and Easter Island. Its rising popularity among discerning adventurers is thanks in part to a blossoming of luxury lodges in the area that offer a tantalizing combination of world-class comfort and active adventure.