A common question at the early stages of planning a trip to this far-flung and stunning region of the world is “What’s the best way to get down to Patagonia, South America?” The answer of course is by flying, however there are different routes, airports of access, land transfer logistics, and timing considerations to take into account to assure your travels are as smooth, efficient, and cost effective as possible. Patagonia, or the southernmost region of South America, spans both Chile and Argentina and is accessed via either countries capital city.